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Atomic Resolution Structure of the Orotidine 5′-Monophosphate Decarboxylase Product Complex Combined with Surface Plasmon Resonance Analysis: IMPLICATIONS FOR THE CATALYTIC MECHANISM

Orotidine 5′-monophosphate decarboxylase (ODCase) accelerates the decarboxylation of its substrate by 17 orders of magnitude. One argument brought forward against steric/electrostatic repulsion causing substrate distortion at the carboxylate substituent as part of the catalysis has been the weak bin...

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Detalhes bibliográficos
Main Authors: Fujihashi, Masahiro, Mito, Kazuya, Pai, Emil F., Miki, Kunio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3610973/
https://ncbi.nlm.nih.gov/pubmed/23395822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.427252
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