Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors

BACKGROUND: Small molecule modulators of epigenetic processes are currently sought as basic probes for biochemical mechanisms, and as starting points for development of therapeutic agents. N(ε)-Methylation of lysine residues on histone tails is one of a number of post-translational modifications tha...

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Detalhes bibliográficos
Main Authors: King, Oliver N. F., Li, Xuan Shirley, Sakurai, Masaaki, Kawamura, Akane, Rose, Nathan R., Ng, Stanley S., Quinn, Amy M., Rai, Ganesha, Mott, Bryan T., Beswick, Paul, Klose, Robert J., Oppermann, Udo, Jadhav, Ajit, Heightman, Tom D., Maloney, David J., Schofield, Christopher J., Simeonov, Anton
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990756/
https://ncbi.nlm.nih.gov/pubmed/21124847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015535
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