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Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors

BACKGROUND: Small molecule modulators of epigenetic processes are currently sought as basic probes for biochemical mechanisms, and as starting points for development of therapeutic agents. N(ε)-Methylation of lysine residues on histone tails is one of a number of post-translational modifications tha...

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Hlavní autoři: King, Oliver N. F., Li, Xuan Shirley, Sakurai, Masaaki, Kawamura, Akane, Rose, Nathan R., Ng, Stanley S., Quinn, Amy M., Rai, Ganesha, Mott, Bryan T., Beswick, Paul, Klose, Robert J., Oppermann, Udo, Jadhav, Ajit, Heightman, Tom D., Maloney, David J., Schofield, Christopher J., Simeonov, Anton
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990756/
https://ncbi.nlm.nih.gov/pubmed/21124847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015535
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