A Miniaturized Screen for Inhibitors of Jumonji Histone Demethylases

2-Oxoglutarate and Fe(II) dependent oxygenases are a major class of N(ε)-methyl lysine demethylases that are involved in epigenetic regulation. Assays suitable for implementation in a high-throughput manner have been lacking for these enzymes. Here, we describe the design and implementation of a rob...

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Main Authors: Sakurai, Masaaki, Rose, Nathan R., Schultz, Lena, Quinn, Amy, Jadhav, Ajit, Ng, Stanley S., Oppermann, Udo, Schofield, Christopher J., Simeonov, Anton
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401096/
https://ncbi.nlm.nih.gov/pubmed/20094655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b912993f
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