A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth

The pharmacological inhibition of general transcriptional regulators has the potential to block growth through targeting multiple tumorigenic signaling pathways simultaneously. Here, using an innovative cell-based screen, we identify a structurally unique small molecule (named JIB-04) which specific...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Wang, Lei, Chang, Jianjun, Varghese, Diana, Dellinger, Michael, Kumar, Subodh, Best, Anne M., Ruiz, Julio, Bruick, Richard, Peña-Llopis, Samuel, Xu, Junjie, Babinski, David J., Frantz, Doug E., Brekken, Rolf A., Quinn, Amy M., Simeonov, Anton, Easmon, Johnny, Martinez, Elisabeth D.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3724450/
https://ncbi.nlm.nih.gov/pubmed/23792809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3035
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares