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A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth
The pharmacological inhibition of general transcriptional regulators has the potential to block growth through targeting multiple tumorigenic signaling pathways simultaneously. Here, using an innovative cell-based screen, we identify a structurally unique small molecule (named JIB-04) which specific...
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| Main Authors: | , , , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3724450/ https://ncbi.nlm.nih.gov/pubmed/23792809 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3035 |
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