Reconstitution of Nucleosome Demethylation and Catalytic Properties of a Jumonji Histone Demethylase

Jumonji histone demethylases catalyze removal of methyl marks from lysine residues in histone proteins within nucleosomes. Here, we show that the catalytic domain of demethylase JMJD2A (cJMJD2A) utilizes a distributive mechanism to remove the histone H3 lysine 9 trimethyl mark. By developing a metho...

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Main Authors: Shiau, Carrie, Trnka, Michael J., Bozicevic, Alen, Torres, Idelisse Ortiz, Al-Sady, Bassem, Burlingame, Alma L., Narlikar, Geeta J., Fujimori, Danica Galonić
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3704229/
https://ncbi.nlm.nih.gov/pubmed/23601638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2013.03.008
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