Reconstitution of Nucleosome Demethylation and Catalytic Properties of a Jumonji Histone Demethylase

Jumonji histone demethylases catalyze removal of methyl marks from lysine residues in histone proteins within nucleosomes. Here, we show that the catalytic domain of demethylase JMJD2A (cJMJD2A) utilizes a distributive mechanism to remove the histone H3 lysine 9 trimethyl mark. By developing a metho...

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Detaylı Bibliyografya
Asıl Yazarlar: Shiau, Carrie, Trnka, Michael J., Bozicevic, Alen, Torres, Idelisse Ortiz, Al-Sady, Bassem, Burlingame, Alma L., Narlikar, Geeta J., Fujimori, Danica Galonić
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3704229/
https://ncbi.nlm.nih.gov/pubmed/23601638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2013.03.008
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