Reconstitution of Nucleosome Demethylation and Catalytic Properties of a Jumonji Histone Demethylase

Jumonji histone demethylases catalyze removal of methyl marks from lysine residues in histone proteins within nucleosomes. Here, we show that the catalytic domain of demethylase JMJD2A (cJMJD2A) utilizes a distributive mechanism to remove the histone H3 lysine 9 trimethyl mark. By developing a metho...

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Detalhes bibliográficos
Main Authors: Shiau, Carrie, Trnka, Michael J., Bozicevic, Alen, Torres, Idelisse Ortiz, Al-Sady, Bassem, Burlingame, Alma L., Narlikar, Geeta J., Fujimori, Danica Galonić
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3704229/
https://ncbi.nlm.nih.gov/pubmed/23601638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2013.03.008
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