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Reconstitution of Nucleosome Demethylation and Catalytic Properties of a Jumonji Histone Demethylase
Jumonji histone demethylases catalyze removal of methyl marks from lysine residues in histone proteins within nucleosomes. Here, we show that the catalytic domain of demethylase JMJD2A (cJMJD2A) utilizes a distributive mechanism to remove the histone H3 lysine 9 trimethyl mark. By developing a metho...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2013
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3704229/ https://ncbi.nlm.nih.gov/pubmed/23601638 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2013.03.008 |
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