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The nucleosomal acidic patch relieves auto-inhibition by the ISWI remodeler SNF2h

ISWI family chromatin remodeling motors use sophisticated autoinhibition mechanisms to control nucleosome sliding. Yet how the different autoinhibitory domains are regulated is not well understood. Here we show that an acidic patch formed by histones H2A and H2B of the nucleosome relieves the autoin...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Gamarra, Nathan, Johnson, Stephanie L, Trnka, Michael J, Burlingame, Alma L, Narlikar, Geeta J
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5976439/
https://ncbi.nlm.nih.gov/pubmed/29664398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.35322
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