Reconstitution of Nucleosome Demethylation and Catalytic Properties of a Jumonji Histone Demethylase

Jumonji histone demethylases catalyze removal of methyl marks from lysine residues in histone proteins within nucleosomes. Here, we show that the catalytic domain of demethylase JMJD2A (cJMJD2A) utilizes a distributive mechanism to remove the histone H3 lysine 9 trimethyl mark. By developing a metho...

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Autores principales: Shiau, Carrie, Trnka, Michael J., Bozicevic, Alen, Torres, Idelisse Ortiz, Al-Sady, Bassem, Burlingame, Alma L., Narlikar, Geeta J., Fujimori, Danica Galonić
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3704229/
https://ncbi.nlm.nih.gov/pubmed/23601638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2013.03.008
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