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Sugar binding induces the same global conformational change in purified LacY as in the native bacterial membrane

Many independent lines of evidence indicate that the lactose permease of Escherichia coli (LacY) is highly dynamic and that sugar binding causes closing of a large inward-facing cavity with opening of a wide outward-facing hydrophilic cavity. Therefore, lactose/H(+) symport catalyzed by LacY very li...

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Bibliografiske detaljer
Main Authors: Nie, Yiling, Kaback, H. Ronald
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906848/
https://ncbi.nlm.nih.gov/pubmed/20457922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004515107
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