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Sugar binding induces the same global conformational change in purified LacY as in the native bacterial membrane
Many independent lines of evidence indicate that the lactose permease of Escherichia coli (LacY) is highly dynamic and that sugar binding causes closing of a large inward-facing cavity with opening of a wide outward-facing hydrophilic cavity. Therefore, lactose/H(+) symport catalyzed by LacY very li...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2906848/ https://ncbi.nlm.nih.gov/pubmed/20457922 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004515107 |
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