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Sugar binding induces the same global conformational change in purified LacY as in the native bacterial membrane

Many independent lines of evidence indicate that the lactose permease of Escherichia coli (LacY) is highly dynamic and that sugar binding causes closing of a large inward-facing cavity with opening of a wide outward-facing hydrophilic cavity. Therefore, lactose/H(+) symport catalyzed by LacY very li...

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Detaylı Bibliyografya
Asıl Yazarlar: Nie, Yiling, Kaback, H. Ronald
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2010
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906848/
https://ncbi.nlm.nih.gov/pubmed/20457922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004515107
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