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Sugar binding induces the same global conformational change in purified LacY as in the native bacterial membrane
Many independent lines of evidence indicate that the lactose permease of Escherichia coli (LacY) is highly dynamic and that sugar binding causes closing of a large inward-facing cavity with opening of a wide outward-facing hydrophilic cavity. Therefore, lactose/H(+) symport catalyzed by LacY very li...
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| Główni autorzy: | , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
National Academy of Sciences
2010
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2906848/ https://ncbi.nlm.nih.gov/pubmed/20457922 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004515107 |
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