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Sugar binding induces the same global conformational change in purified LacY as in the native bacterial membrane

Many independent lines of evidence indicate that the lactose permease of Escherichia coli (LacY) is highly dynamic and that sugar binding causes closing of a large inward-facing cavity with opening of a wide outward-facing hydrophilic cavity. Therefore, lactose/H(+) symport catalyzed by LacY very li...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Nie, Yiling, Kaback, H. Ronald
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906848/
https://ncbi.nlm.nih.gov/pubmed/20457922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004515107
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