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ZAP-70: An Essential Kinase in T-cell Signaling
ZAP-70 is a cytoplasmic protein tyrosine kinase that plays a critical role in the events involved in initiating T-cell responses by the antigen receptor. Here we review the structure of ZAP-70, its regulation, its role in development and in disease. We also describe a model experimental system in wh...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Cold Spring Harbor Laboratory Press
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2857167/ https://ncbi.nlm.nih.gov/pubmed/20452964 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a002279 |
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