ZAP-70: An Essential Kinase in T-cell Signaling

ZAP-70 is a cytoplasmic protein tyrosine kinase that plays a critical role in the events involved in initiating T-cell responses by the antigen receptor. Here we review the structure of ZAP-70, its regulation, its role in development and in disease. We also describe a model experimental system in wh...

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Bibliographic Details
Main Authors: Wang, Haopeng, Kadlecek, Theresa A., Au-Yeung, Byron B., Goodfellow, Hanna E. Sjölin, Hsu, Lih-Yun, Freedman, Tanya S., Weiss, Arthur
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2010
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Perspectives
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857167/
https://ncbi.nlm.nih.gov/pubmed/20452964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a002279
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