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A genetically selective inhibitor reveals a ZAP-70 catalytic-independent function in T(REG) cells
To investigate the role of the kinase zeta-associated protein of 70 kDa (ZAP-70) in T cells, we generated mice expressing a ZAP-70 mutant whose catalytic activity can be selectively blocked by a small molecule inhibitor. Conventional naïve, effector and memory T cells were dependent on ZAP-70 kinase...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3711183/ https://ncbi.nlm.nih.gov/pubmed/21037577 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1955 |
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