A genetically selective inhibitor reveals a ZAP-70 catalytic-independent function in T(REG) cells

To investigate the role of the kinase zeta-associated protein of 70 kDa (ZAP-70) in T cells, we generated mice expressing a ZAP-70 mutant whose catalytic activity can be selectively blocked by a small molecule inhibitor. Conventional naïve, effector and memory T cells were dependent on ZAP-70 kinase...

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Main Authors: Au-Yeung, Byron B., Levin, Susan E., Zhang, Chao, Hsu, Lih-Yun, Cheng, Debra A., Killeen, Nigel, Shokat, Kevan M., Weiss, Arthur
格式: Artigo
語言:Inglês
出版: 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711183/
https://ncbi.nlm.nih.gov/pubmed/21037577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1955
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