Destabilizing the autoinhibitory conformation of Zap70 induces up-regulation of inhibitory receptors and T cell unresponsiveness

Por Hsu, Lih-Yun, Cheng, Debra A., Chen, Yiling, Liang, Hong-Erh, Weiss, Arthur
Publicado no J Exp Med (2017)

A genetically selective inhibitor reveals a ZAP-70 catalytic-independent function in T(REG) cells

Por Au-Yeung, Byron B., Levin, Susan E., Zhang, Chao, Hsu, Lih-Yun, Cheng, Debra A., Killeen, Nigel, Shokat, Kevan M., Weiss, Arthur
Publicado em 2010

Quantitative and Temporal Requirements Revealed for Zap-70 Catalytic Activity During T Cell Development

Por Au-Yeung, Byron B., Melichar, Heather J., Ross, Jenny O., Cheng, Debra A., Zikherman, Julie, Shokat, Kevan M., Robey, Ellen A., Weiss, Arthur
Publicado em 2014

A sharp T-cell antigen receptor signaling threshold for T-cell proliferation

Por Au-Yeung, Byron B., Zikherman, Julie, Mueller, James L., Ashouri, Judith F., Matloubian, Mehrdad, Cheng, Debra A., Chen, Yiling, Shokat, Kevan M., Weiss, Arthur
Publicado em 2014

Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis

Por Ashouri, Judith F., Hsu, Lih-Yun, Yu, Steven, Rychkov, Dmitry, Chen, Yiling, Cheng, Debra A., Sirota, Marina, Hansen, Erik, Lattanza, Lisa, Zikherman, Julie, Weiss, Arthur
Publicado no Proc Natl Acad Sci U S A (2019)

The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway

Por Goodfellow, Hanna Sjölin, Frushicheva, Maria P., Ji, Qinqin, Cheng, Debra A, Kadlecek, Theresa A., Cantor, Aaron J., Kuriyan, John, Chakraborty, Arup K., Salomon, Arthur, Weiss, Arthur
Publicado no Sci Signal (2015)