The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway

T cell activation must be properly regulated to ensure normal T cell development and effective immune responses to pathogens and transformed cells while avoiding autoimmunity. The mechanisms controlling the fine-tuning of T cell receptor (TCR) signaling and T cell activation are unclear. The Syk fam...

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Veröffentlicht in:Sci Signal
Hauptverfasser: Goodfellow, Hanna Sjölin, Frushicheva, Maria P., Ji, Qinqin, Cheng, Debra A, Kadlecek, Theresa A., Cantor, Aaron J., Kuriyan, John, Chakraborty, Arup K., Salomon, Arthur, Weiss, Arthur
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4445242/
https://ncbi.nlm.nih.gov/pubmed/25990959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2005596
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