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Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response

The delivery of signals from the activated T cell antigen receptor (TCR) inside the cell relies on the protein tyrosine kinase ZAP-70 (ζ-associated protein of 70 kDa). A recent crystal structure of inactive full-length ZAP-70 suggests that a central interface formed by the docking of the two SH2 dom...

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Detalhes bibliográficos
Main Authors: Deindl, Sebastian, Kadlecek, Theresa A., Cao, Xiaoxian, Kuriyan, John, Weiss, Arthur
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2778570/
https://ncbi.nlm.nih.gov/pubmed/19920178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911512106
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