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Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker
Serial activation of the tyrosine kinases Lck and ZAP-70 initiates signaling downstream of the T cell receptor. We previously reported the structure of an autoinhibited ZAP-70 variant in which two regulatory tyrosine residues (315 and 319) in the SH2-kinase linker were replaced by phenylalanine. We...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Microbiology
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3648074/ https://ncbi.nlm.nih.gov/pubmed/23530057 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01637-12 |
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