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Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT
T cell antigen receptor (TCR) signaling requires the sequential activities of the kinases Lck and Zap70. Upon TCR stimulation, Lck phosphorylates the TCR, leading to the recruitment, phosphorylation, and activation of Zap70. Lck binds to and stabilizes phosho-Zap70 using its SH2 domain, and Zap70 ph...
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| Publié dans: | Nat Immunol |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6202249/ https://ncbi.nlm.nih.gov/pubmed/29915297 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-018-0131-1 |
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