Intramolecular Regulatory Switch in ZAP-70: Analogy with Receptor Tyrosine Kinases

ZAP-70, a Syk family cytoplasmic protein tyrosine kinase (PTK), is required to couple the activated T-cell antigen receptor (TCR) to downstream signaling pathways. It contains two tandem SH2 domains that bind to phosphorylated TCR subunits and a C-terminal catalytic domain. The region connecting the...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Brdicka, Tomas, Kadlecek, Theresa A., Roose, Jeroen P., Pastuszak, Alexander W., Weiss, Arthur
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Microbiology 2005
विषय:
Signal Transduction
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC1140569/
https://ncbi.nlm.nih.gov/pubmed/15923611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.12.4924-4933.2005
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