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Intramolecular Regulatory Switch in ZAP-70: Analogy with Receptor Tyrosine Kinases
ZAP-70, a Syk family cytoplasmic protein tyrosine kinase (PTK), is required to couple the activated T-cell antigen receptor (TCR) to downstream signaling pathways. It contains two tandem SH2 domains that bind to phosphorylated TCR subunits and a C-terminal catalytic domain. The region connecting the...
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| Glavni autori: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Microbiology
2005
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1140569/ https://ncbi.nlm.nih.gov/pubmed/15923611 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.12.4924-4933.2005 |
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