Intramolecular Regulatory Switch in ZAP-70: Analogy with Receptor Tyrosine Kinases

ZAP-70, a Syk family cytoplasmic protein tyrosine kinase (PTK), is required to couple the activated T-cell antigen receptor (TCR) to downstream signaling pathways. It contains two tandem SH2 domains that bind to phosphorylated TCR subunits and a C-terminal catalytic domain. The region connecting the...

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Main Authors: Brdicka, Tomas, Kadlecek, Theresa A., Roose, Jeroen P., Pastuszak, Alexander W., Weiss, Arthur
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2005
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1140569/
https://ncbi.nlm.nih.gov/pubmed/15923611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.12.4924-4933.2005
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