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A disease-associated mutation that weakens ZAP70 autoinhibition enhances responses to weak and self ligands
The cytoplasmic kinase ZAP70 is critical for T cell antigen receptor (TCR) signaling. The R360P mutation in ZAP70 is responsible for an early onset familial autoimmune syndrome. The structural location and biochemical signaling effects of the R360P mutation are consistent with weakening of the autoi...
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| 出版年: | Sci Signal |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2021
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8009134/ https://ncbi.nlm.nih.gov/pubmed/33531381 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.abc4479 |
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