Cargando...

A disease-associated mutation that weakens ZAP70 autoinhibition enhances responses to weak and self ligands

The cytoplasmic kinase ZAP70 is critical for T cell antigen receptor (TCR) signaling. The R360P mutation in ZAP70 is responsible for an early onset familial autoimmune syndrome. The structural location and biochemical signaling effects of the R360P mutation are consistent with weakening of the autoi...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Sci Signal
Autores principales: Shen, Lin, Matloubian, Mehrdad, Kadlecek, Theresa A., Weiss, Arthur
Formato: Artigo
Lenguaje:Inglês
Publicado: 2021
Materias:
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8009134/
https://ncbi.nlm.nih.gov/pubmed/33531381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.abc4479
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!