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Quantitative and Temporal Requirements Revealed for Zap-70 Catalytic Activity During T Cell Development
The catalytic activity of Zap-70 is crucial for T cell receptor (TCR) signaling, but the quantitative and temporal requirements for its function in thymocyte development are not known. Using a chemical-genetic system to selectively and reversibly inhibit Zap-70 catalytic activity in a model of synch...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4095875/ https://ncbi.nlm.nih.gov/pubmed/24908390 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2918 |
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