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Distinct phases in the positive selection of CD8(+) T cells distinguished by intrathymic migration and T-cell receptor signaling patterns
Positive selection of CD8 T cells in the thymus is thought to be a multistep process lasting 3–4 d; however, the discrete steps involved are poorly understood. Here, we examine phenotypic changes, calcium signaling, and intrathymic migration in a synchronized cohort of MHC class I-specific thymocyte...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4078834/ https://ncbi.nlm.nih.gov/pubmed/24927565 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1408482111 |
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