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Distinct temporal pattern of T cell receptor signals during positive versus negative selection in situ
The recognition by the T cell receptor (TCR) of self peptides presented by the major histocompatibility complex (MHC) controls T cell fate in the thymus, with weak signals inducing survival (the process of positive selection) and stronger signals inducing death (negative selection). In vitro studies...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4078262/ https://ncbi.nlm.nih.gov/pubmed/24129702 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2004400 |
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