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Distinct temporal pattern of T cell receptor signals during positive versus negative selection in situ

The recognition by the T cell receptor (TCR) of self peptides presented by the major histocompatibility complex (MHC) controls T cell fate in the thymus, with weak signals inducing survival (the process of positive selection) and stronger signals inducing death (negative selection). In vitro studies...

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Bibliografiske detaljer
Main Authors: Melichar, Heather J., Ross, Jenny O., Herzmark, Paul, Hogquist, Kristin A., Robey, Ellen A.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4078262/
https://ncbi.nlm.nih.gov/pubmed/24129702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2004400
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