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Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL
T cell receptor (TCR) activation leads to a dramatic reorganisation of both membranes and receptors as the immunological synapse forms. Using a genetic model to rapidly inhibit Zap70 catalytic activity we examined synapse formation between cytotoxic T lymphocytes and their targets. In the absence of...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
eLife Sciences Publications, Ltd
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3936284/ https://ncbi.nlm.nih.gov/pubmed/24596147 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01310 |
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