Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer

RAS and RHO proteins, which contribute to tumorigenesis and metastasis, undergo posttranslational modification with an isoprenyl lipid by protein farnesyltransferase (FTase) or protein geranylgeranyltransferase-I (GGTase-I). Inhibitors of FTase and GGTase-I were developed to block RAS-induced malign...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Liu, Meng, Sjogren, Anna-Karin M., Karlsson, Christin, Ibrahim, Mohamed X., Andersson, Karin M. E., Olofsson, Frida J., Wahlstrom, Annika M., Dalin, Martin, Yu, Huiming, Chen, Zhenggang, Yang, Shao H., Young, Stephen G., Bergo, Martin O.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852017/
https://ncbi.nlm.nih.gov/pubmed/20308544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908396107
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars