Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice

RHO family proteins are important for the function of inflammatory cells. They are modified with a 20-carbon geranylgeranyl lipid in a process catalyzed by protein geranylgeranyltransferase type I (GGTase-I). Geranylgeranylation is viewed as essential for the membrane targeting and activity of RHO p...

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Detalhes bibliográficos
Main Authors: Khan, Omar M., Ibrahim, Mohamed X., Jonsson, Ing-Marie, Karlsson, Christin, Liu, Meng, Sjogren, Anna-Karin M., Olofsson, Frida J., Brisslert, Mikael, Andersson, Sofia, Ohlsson, Claes, Hultén, Lillemor Mattsson, Bokarewa, Maria, Bergo, Martin O.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3026725/
https://ncbi.nlm.nih.gov/pubmed/21266780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43758
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