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GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS–induced lung cancer
Protein geranylgeranyltransferase type I (GGTase-I) is responsible for the posttranslational lipidation of CAAX proteins such as RHOA, RAC1, and cell division cycle 42 (CDC42). Inhibition of GGTase-I has been suggested as a strategy to treat cancer and a host of other diseases. Although several GGTa...
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| Главные авторы: | , , , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Clinical Investigation
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1857236/ https://ncbi.nlm.nih.gov/pubmed/17476360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30868 |
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