Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer

RAS and RHO proteins, which contribute to tumorigenesis and metastasis, undergo posttranslational modification with an isoprenyl lipid by protein farnesyltransferase (FTase) or protein geranylgeranyltransferase-I (GGTase-I). Inhibitors of FTase and GGTase-I were developed to block RAS-induced malign...

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Bibliographische Detailangaben
Hauptverfasser: Liu, Meng, Sjogren, Anna-Karin M., Karlsson, Christin, Ibrahim, Mohamed X., Andersson, Karin M. E., Olofsson, Frida J., Wahlstrom, Annika M., Dalin, Martin, Yu, Huiming, Chen, Zhenggang, Yang, Shao H., Young, Stephen G., Bergo, Martin O.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2010
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852017/
https://ncbi.nlm.nih.gov/pubmed/20308544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908396107
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