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Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer
RAS and RHO proteins, which contribute to tumorigenesis and metastasis, undergo posttranslational modification with an isoprenyl lipid by protein farnesyltransferase (FTase) or protein geranylgeranyltransferase-I (GGTase-I). Inhibitors of FTase and GGTase-I were developed to block RAS-induced malign...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2852017/ https://ncbi.nlm.nih.gov/pubmed/20308544 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908396107 |
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