Loading...

Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer

RAS and RHO proteins, which contribute to tumorigenesis and metastasis, undergo posttranslational modification with an isoprenyl lipid by protein farnesyltransferase (FTase) or protein geranylgeranyltransferase-I (GGTase-I). Inhibitors of FTase and GGTase-I were developed to block RAS-induced malign...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Liu, Meng, Sjogren, Anna-Karin M., Karlsson, Christin, Ibrahim, Mohamed X., Andersson, Karin M. E., Olofsson, Frida J., Wahlstrom, Annika M., Dalin, Martin, Yu, Huiming, Chen, Zhenggang, Yang, Shao H., Young, Stephen G., Bergo, Martin O.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852017/
https://ncbi.nlm.nih.gov/pubmed/20308544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908396107
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!