Inactivating Icmt ameliorates K-RAS–induced myeloproliferative disease

Hyperactive signaling through the RAS proteins is involved in the pathogenesis of many forms of cancer. The RAS proteins and many other intracellular signaling proteins are either farnesylated or geranylgeranylated at a carboxyl-terminal cysteine. That isoprenylcysteine is then carboxyl methylated b...

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Bibliografiset tiedot
Päätekijät: Wahlstrom, Annika M., Cutts, Briony A., Liu, Meng, Lindskog, Annika, Karlsson, Christin, Sjogren, Anna-Karin M., Andersson, Karin M. E., Young, Stephen G., Bergo, Martin O.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Hematology 2008
Aiheet:
Neoplasia
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2515151/
https://ncbi.nlm.nih.gov/pubmed/18502828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-06-094060
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