Inactivating Icmt ameliorates K-RAS–induced myeloproliferative disease

Hyperactive signaling through the RAS proteins is involved in the pathogenesis of many forms of cancer. The RAS proteins and many other intracellular signaling proteins are either farnesylated or geranylgeranylated at a carboxyl-terminal cysteine. That isoprenylcysteine is then carboxyl methylated b...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Wahlstrom, Annika M., Cutts, Briony A., Liu, Meng, Lindskog, Annika, Karlsson, Christin, Sjogren, Anna-Karin M., Andersson, Karin M. E., Young, Stephen G., Bergo, Martin O.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2008
Pynciau:
Neoplasia
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2515151/
https://ncbi.nlm.nih.gov/pubmed/18502828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-06-094060
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg