Inactivating Icmt ameliorates K-RAS–induced myeloproliferative disease

Hyperactive signaling through the RAS proteins is involved in the pathogenesis of many forms of cancer. The RAS proteins and many other intracellular signaling proteins are either farnesylated or geranylgeranylated at a carboxyl-terminal cysteine. That isoprenylcysteine is then carboxyl methylated b...

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Hlavní autoři: Wahlstrom, Annika M., Cutts, Briony A., Liu, Meng, Lindskog, Annika, Karlsson, Christin, Sjogren, Anna-Karin M., Andersson, Karin M. E., Young, Stephen G., Bergo, Martin O.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2008
Témata:
Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2515151/
https://ncbi.nlm.nih.gov/pubmed/18502828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-06-094060
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