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Inactivating Icmt ameliorates K-RAS–induced myeloproliferative disease
Hyperactive signaling through the RAS proteins is involved in the pathogenesis of many forms of cancer. The RAS proteins and many other intracellular signaling proteins are either farnesylated or geranylgeranylated at a carboxyl-terminal cysteine. That isoprenylcysteine is then carboxyl methylated b...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society of Hematology
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2515151/ https://ncbi.nlm.nih.gov/pubmed/18502828 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-06-094060 |
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