Inactivating Icmt ameliorates K-RAS–induced myeloproliferative disease

Hyperactive signaling through the RAS proteins is involved in the pathogenesis of many forms of cancer. The RAS proteins and many other intracellular signaling proteins are either farnesylated or geranylgeranylated at a carboxyl-terminal cysteine. That isoprenylcysteine is then carboxyl methylated b...

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Bibliografiske detaljer
Main Authors: Wahlstrom, Annika M., Cutts, Briony A., Liu, Meng, Lindskog, Annika, Karlsson, Christin, Sjogren, Anna-Karin M., Andersson, Karin M. E., Young, Stephen G., Bergo, Martin O.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2008
Fag:
Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2515151/
https://ncbi.nlm.nih.gov/pubmed/18502828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-06-094060
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