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Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf

Isoprenylcysteine carboxyl methyltransferase (Icmt) methylates the carboxyl-terminal isoprenylcysteine of CAAX proteins (e.g., Ras and Rho proteins). In the case of the Ras proteins, carboxyl methylation is important for targeting of the proteins to the plasma membrane. We hypothesized that a knocko...

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Detaylı Bibliyografya
Asıl Yazarlar: Bergo, Martin O., Gavino, Bryant J., Hong, Christine, Beigneux, Anne P., McMahon, Martin, Casey, Patrick J., Young, Stephen G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2004
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC338259/
https://ncbi.nlm.nih.gov/pubmed/14966563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200418829
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