Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf

Isoprenylcysteine carboxyl methyltransferase (Icmt) methylates the carboxyl-terminal isoprenylcysteine of CAAX proteins (e.g., Ras and Rho proteins). In the case of the Ras proteins, carboxyl methylation is important for targeting of the proteins to the plasma membrane. We hypothesized that a knocko...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Bergo, Martin O., Gavino, Bryant J., Hong, Christine, Beigneux, Anne P., McMahon, Martin, Casey, Patrick J., Young, Stephen G.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 2004
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC338259/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14966563/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI18829
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