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Raf induces TGFβ production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells

c-Raf-1 is a major effector of Ras proteins, responsible for activation of the ERK MAP kinase pathway and a critical regulator of both normal growth and oncogenic transformation. Using an inducible form of Raf in MDCK cells, we have shown that sustained activation of Raf alone is able to induce the...

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Udgivet i:Genes Dev
Principais autores: Lehmann, Kerstin, Janda, Elzbieta, Pierreux, Christophe E., Rytömaa, Marjatta, Schulze, Almut, McMahon, Martin, Hill, Caroline S., Beug, Hartmut, Downward, Julian
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2000
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316988/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11040215/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.181700
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