Raf induces TGFβ production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells

c-Raf-1 is a major effector of Ras proteins, responsible for activation of the ERK MAP kinase pathway and a critical regulator of both normal growth and oncogenic transformation. Using an inducible form of Raf in MDCK cells, we have shown that sustained activation of Raf alone is able to induce the...

Descripción completa

Detalles Bibliográficos

Publicado en:	Genes Dev
Autores principales:	Lehmann, Kerstin, Janda, Elzbieta, Pierreux, Christophe E., Rytömaa, Marjatta, Schulze, Almut, McMahon, Martin, Hill, Caroline S., Beug, Hartmut, Downward, Julian
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Cold Spring Harbor Laboratory Press 2000
Materias:	Research Paper
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316988/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11040215/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.181700
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!