Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf

Isoprenylcysteine carboxyl methyltransferase (Icmt) methylates the carboxyl-terminal isoprenylcysteine of CAAX proteins (e.g., Ras and Rho proteins). In the case of the Ras proteins, carboxyl methylation is important for targeting of the proteins to the plasma membrane. We hypothesized that a knocko...

Full description

Saved in:
Bibliographic Details
Main Authors: Bergo, Martin O., Gavino, Bryant J., Hong, Christine, Beigneux, Anne P., McMahon, Martin, Casey, Patrick J., Young, Stephen G.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2004
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC338259/
https://ncbi.nlm.nih.gov/pubmed/14966563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200418829
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items