Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf

Isoprenylcysteine carboxyl methyltransferase (Icmt) methylates the carboxyl-terminal isoprenylcysteine of CAAX proteins (e.g., Ras and Rho proteins). In the case of the Ras proteins, carboxyl methylation is important for targeting of the proteins to the plasma membrane. We hypothesized that a knocko...

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Bibliografski detalji
Izdano u:J Clin Invest
Glavni autori: Bergo, Martin O., Gavino, Bryant J., Hong, Christine, Beigneux, Anne P., McMahon, Martin, Casey, Patrick J., Young, Stephen G.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2004
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Article
Online pristup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC338259/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14966563/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI18829
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