Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf
Isoprenylcysteine carboxyl methyltransferase (Icmt) methylates the carboxyl-terminal isoprenylcysteine of CAAX proteins (e.g., Ras and Rho proteins). In the case of the Ras proteins, carboxyl methylation is important for targeting of the proteins to the plasma membrane. We hypothesized that a knocko...
Kaydedildi:
| Yayımlandı: | J Clin Invest |
|---|---|
| Asıl Yazarlar: | , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society for Clinical Investigation
2004
|
| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC338259/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14966563/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI18829 |
| Etiketler: |
Etiket eklenmemiş, İlk siz ekleyin!
|