Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf

Isoprenylcysteine carboxyl methyltransferase (Icmt) methylates the carboxyl-terminal isoprenylcysteine of CAAX proteins (e.g., Ras and Rho proteins). In the case of the Ras proteins, carboxyl methylation is important for targeting of the proteins to the plasma membrane. We hypothesized that a knocko...

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Dades bibliogràfiques

Publicat a:	J Clin Invest
Autors principals:	Bergo, Martin O., Gavino, Bryant J., Hong, Christine, Beigneux, Anne P., McMahon, Martin, Casey, Patrick J., Young, Stephen G.
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Clinical Investigation 2004
Matèries:	Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC338259/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14966563/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI18829
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