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Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf

Isoprenylcysteine carboxyl methyltransferase (Icmt) methylates the carboxyl-terminal isoprenylcysteine of CAAX proteins (e.g., Ras and Rho proteins). In the case of the Ras proteins, carboxyl methylation is important for targeting of the proteins to the plasma membrane. We hypothesized that a knocko...

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Gepubliceerd in:J Clin Invest
Hoofdauteurs: Bergo, Martin O., Gavino, Bryant J., Hong, Christine, Beigneux, Anne P., McMahon, Martin, Casey, Patrick J., Young, Stephen G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2004
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Article
Online toegang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC338259/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14966563/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI18829
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