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Inactivating Icmt ameliorates K-RAS–induced myeloproliferative disease
Hyperactive signaling through the RAS proteins is involved in the pathogenesis of many forms of cancer. The RAS proteins and many other intracellular signaling proteins are either farnesylated or geranylgeranylated at a carboxyl-terminal cysteine. That isoprenylcysteine is then carboxyl methylated b...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2515151/ https://ncbi.nlm.nih.gov/pubmed/18502828 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-06-094060 |
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