Targeting filamin A reduces K-RAS–induced lung adenocarcinomas and endothelial response to tumor growth in mice

BACKGROUND: Many human cancer cells express filamin A (FLNA), an actin-binding structural protein that interacts with a diverse set of cell signaling proteins, but little is known about the biological importance of FLNA in tumor development. FLNA is also expressed in endothelial cells, which may be...

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Main Authors: Nallapalli, Rajesh K, Ibrahim, Mohamed X, Zhou, Alex X, Bandaru, Sashidar, Sunkara, Sai Naresh, Redfors, Björn, Pazooki, David, Zhang, Yin, Borén, Jan, Cao, Yihai, Bergo, Martin O, Akyürek, Levent M
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3441416/
https://ncbi.nlm.nih.gov/pubmed/22857000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-11-50
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