Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development

Mutations in filamin B (FLNB), a gene encoding a cytoplasmic actin-binding protein, have been found in human skeletal disorders, including boomerang dysplasia, spondylocarpotarsal syndrome, Larsen syndrome, and atelosteogenesis phenotypes I and III. To examine the role of FLNB in vivo, we generated...

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Dettagli Bibliografici
Autori principali: Zhou, Xianghua, Tian, Fei, Sandzén, Johan, Cao, Renhai, Flaberg, Emilie, Szekely, Laszlo, Cao, Yihai, Ohlsson, Claes, Bergo, Martin O., Borén, Jan, Akyürek, Levent M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2007
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1820684/
https://ncbi.nlm.nih.gov/pubmed/17360453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0608360104
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