Hypoxia-induced and calpain-dependent cleavage of filamin A regulates the hypoxic response

The cellular response to hypoxia is regulated by hypoxia-inducible factor-1α and -2α (HIF-1α and -2α). We have discovered that filamin A (FLNA), a large cytoskeletal actin-binding protein, physically interacts with HIF-1α and promotes tumor growth and angiogenesis. Hypoxia induces a calpain-dependen...

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Detalhes bibliográficos
Main Authors: Zheng, Xiaowei, Zhou, Alex-Xianghua, Rouhi, Pegah, Uramoto, Hidetaka, Borén, Jan, Cao, Yihai, Pereira, Teresa, Akyürek, Levent M., Poellinger, Lorenz
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932879/
https://ncbi.nlm.nih.gov/pubmed/24550283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1320815111
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