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Hypoxia-induced and calpain-dependent cleavage of filamin A regulates the hypoxic response
The cellular response to hypoxia is regulated by hypoxia-inducible factor-1α and -2α (HIF-1α and -2α). We have discovered that filamin A (FLNA), a large cytoskeletal actin-binding protein, physically interacts with HIF-1α and promotes tumor growth and angiogenesis. Hypoxia induces a calpain-dependen...
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| Hlavní autoři: | , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3932879/ https://ncbi.nlm.nih.gov/pubmed/24550283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1320815111 |
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