Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer

RAS and RHO proteins, which contribute to tumorigenesis and metastasis, undergo posttranslational modification with an isoprenyl lipid by protein farnesyltransferase (FTase) or protein geranylgeranyltransferase-I (GGTase-I). Inhibitors of FTase and GGTase-I were developed to block RAS-induced malign...

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Detalhes bibliográficos
Main Authors: Liu, Meng, Sjogren, Anna-Karin M., Karlsson, Christin, Ibrahim, Mohamed X., Andersson, Karin M. E., Olofsson, Frida J., Wahlstrom, Annika M., Dalin, Martin, Yu, Huiming, Chen, Zhenggang, Yang, Shao H., Young, Stephen G., Bergo, Martin O.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852017/
https://ncbi.nlm.nih.gov/pubmed/20308544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908396107
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