GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS–induced lung cancer

Protein geranylgeranyltransferase type I (GGTase-I) is responsible for the posttranslational lipidation of CAAX proteins such as RHOA, RAC1, and cell division cycle 42 (CDC42). Inhibition of GGTase-I has been suggested as a strategy to treat cancer and a host of other diseases. Although several GGTa...

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Main Authors: Sjogren, Anna-Karin M., Andersson, Karin M.E., Liu, Meng, Cutts, Briony A., Karlsson, Christin, Wahlstrom, Annika M., Dalin, Martin, Weinbaum, Carolyn, Casey, Patrick J., Tarkowski, Andrej, Swolin, Birgitta, Young, Stephen G., Bergo, Martin O.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2007
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1857236/
https://ncbi.nlm.nih.gov/pubmed/17476360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30868
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